synthesis and cytotoxic activity of novel 9-[hydroxy(substitutedphenyl) methyl]-2,2-dimethyl-2,3,8,9-tetrahydro-4h,10h-pyrano [2,3-f ]chromene-4,10-diones

نویسندگان

babak heidary alizadeh

mohsen vosooghi

mehdi khoobi

azita javidnia

fatemeh panah,

چکیده

chromanone derivatives demonstrate remarkable cytotoxity against a varieties of cancer cell lines. novel 9-[hydroxy(substitutedphenyl)methyl]-2,2-dimethyl-2,3,8,9- tetrahydro-4h,10h-pyrano[2,3-f]chromene-4,10-diones as glyasperin analogues were synthesized in four steps from known 4-chromone 1. the key step was the preparation of chromane dione 5a by regioselective intramolecular cyclization reaction in 85% yield. condensation of 5a with substituted aromatic aldehydes afforded corresponding alpha hydroxybenzyl analogues 6a-6e. the cytotoxic study of the synthesized compounds against breast cancer human cell line (t47d) showed moderate cytotoxic activities (ic50=16-40 μm) compared to the positive control drug vincristin (ic50=2.5 μm).

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Synthesis and Cytotoxic Activity of Novel 9-[Hydroxy(Substitutedphenyl) Methyl]-2,2-Dimethyl-2,3,8,9-Tetrahydro-4H,10H-Pyrano [2,3-f ]Chromene-4,10-Diones

Chromanone derivatives demonstrate remarkable cytotoxity against a varieties of cancer cell lines. Novel 9-[hydroxy(substitutedphenyl)methyl]-2,2-dimethyl-2,3,8,9- tetrahydro-4H,10H-pyrano[2,3-f]chromene-4,10-diones as Glyasperin analogues were synthesized in four steps from known 4-chromone 1. The key step was the preparation of chromane dione 5a by regioselective intramolecular c...

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عنوان ژورنال:
iranian journal of chemistry and chemical engineering (ijcce)

ناشر: iranian institute of research and development in chemical industries (irdci)-acecr

ISSN 1021-9986

دوره 29

شماره 4 2010

میزبانی شده توسط پلتفرم ابری doprax.com

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